Host-Pathogen Interactions in Tuberculosis
نویسنده
چکیده
My presentation will focus on host-cell pathogen interactions in tuberculosis. However, I would first like offer a brief introduction to the tuberculosis disease. I believe it is important to remember that merely an estimated 5-10% of individuals exposed or infected with the Mycobacterium tuberculosis bacteria actually develop tuberculosis. In other words, the human population, as a whole, is extremely resistant to the disease. It is extremely interesting to examine the mechanisms responsible for this resistance.
منابع مشابه
Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions
Metabolic coupling of Mycobacterium tuberculosis to its host is foundational to its pathogenesis. Computational genome-scale metabolic models have shown utility in integrating -omic as well as physiologic data for systemic, mechanistic analysis of metabolism. To date, integrative analysis of host-pathogen interactions using in silico mass-balanced, genome-scale models has not been performed. We...
متن کاملProteomics of Mycobacterium Infection: Moving towards a Better Understanding of Pathogen-Driven Immunomodulation
Intracellular bacteria are responsible for many infectious diseases in humans and have developed diverse mechanisms to interfere with host defense pathways. In particular, intracellular vacuoles are an essential niche used by pathogens to alter cellular and organelle functions, which facilitate replication and survival. Mycobacterium tuberculosis (Mtb), the pathogen causing tuberculosis in huma...
متن کاملUncovering New Pathogen–Host Protein–Protein Interactions by Pairwise Structure Similarity
Pathogens usually evade and manipulate host-immune pathways through pathogen-host protein-protein interactions (PPIs) to avoid being killed by the host immune system. Therefore, uncovering pathogen-host PPIs is critical for determining the mechanisms underlying pathogen infection and survival. In this study, we developed a computational method, which we named pairwise structure similarity (PSS)...
متن کاملIdentification of the INO1 gene of Mycobacterium tuberculosis H37Rv reveals a novel class of inositol-1-phosphate synthase enzyme.
1L-myo-inositol (inositol) is vital for the biogenesis of mycothiol, phosphatidylinositol and glycosylphosphatidylinositol anchors linked to complex carbohydrates in Mycobacterium tuberculosis. All these cellular components are thought to play important roles in host-pathogen interactions and in the survival of the pathogen within the host. However, the inositol biosynthetic pathway in M. tuber...
متن کاملIdentification of Mycobacterium tuberculosis adherence-mediating components: a review of key methods to confirm adhesin function
Anti-adhesion therapy represents a potentially promising avenue for the treatment and prevention of tuberculosis in a post-antibiotic era. Adhesins are surface-exposed microbial structures or molecules that enable pathogenic organisms to adhere to host surfaces, a fundamental step towards host infection. Although several Mycobacterium tuberculosis adhesins have been identified, it is predicted ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008